Penelope Bourbon is an American whiskey brand founded in 2018 by Mike Paladini and Danny Polise. The brand originated from Paladini's desire to create a distinctive bourbon to celebrate the expected birth of his daughter, Penelope. It specializes in blending and producing bourbon and rye whiskeys, offering several expressions designed to appeal to different consumer preferences. In 2023, MGP Ingredients acquired Penelope Bourbon through its Luxco subsidiary, while the founders continued to lead the brand. Its products are distributed throughout the United States and in international markets. The company has developed its identity around craftsmanship, experimentation and the celebration of life's milestones.

Beyond its commercial operations, Penelope Bourbon has participated in cause-related initiatives and promotional partnerships that connect its brand with charitable causes. Its public-facing initiatives have included collaborations associated with cancer awareness and fundraising. However, Penelope Bourbon is primarily a commercial spirits brand rather than an independent charitable foundation, and its charitable activities should be distinguished from those of dedicated grantmaking organizations. Its contributions and partnerships may vary by campaign, making it important to verify individual donations through official announcements or recipient organizations. Through its business operations and selected community initiatives, the brand maintains connections with consumers and organizations across the markets it serves.